Yog tias cov plaub hau poob yog ib qho teeb meem rau cov neeg laus, ces cov hniav lwj (lub npe tshawb fawb caries) yog ib qho teeb meem mob taub hau rau cov neeg ntawm txhua lub hnub nyoog.

Raws li kev txheeb cais, qhov tshwm sim ntawm cov hniav caries ntawm cov tub ntxhais hluas hauv kuv lub teb chaws yog tshaj 50%, qhov tshwm sim ntawm cov hniav caries ntawm cov neeg laus hnub nyoog nruab nrab yog tshaj 80%, thiab cov neeg laus, qhov feem ntau yog tshaj 95%.Yog tias tsis kho rau lub sijhawm, cov kab mob ntawm cov hniav tawv nqaij no yuav ua rau cov kab mob pulpitis thiab apical periodontitis, thiab txawm ua rau cov pob txha alveolar thiab lub puab tsaig, uas yuav cuam tshuam rau kev noj qab haus huv thiab lub neej ntawm tus neeg mob.Tam sim no, tus kab mob no yuav tau ntsib ib tug "nemesis."

Ntawm American Chemical Society (ACS) Virtual Conference thiab Exhibition nyob rau lub caij nplooj zeeg 2020, cov kws tshawb fawb los ntawm University of Illinois ntawm Chicago tau tshaj tawm ib hom tshiab ntawm cerium nanoparticle formulation uas tuaj yeem tiv thaiv kev tsim cov quav hniav thiab cov hniav lwj hauv ib hnub.Tam sim no, cov kws tshawb fawb tau thov rau patent, thiab kev npaj yuav siv dav hauv cov chaw kho hniav yav tom ntej.

Muaj ntau dua 700 hom kab mob hauv tib neeg lub qhov ncauj.Ntawm lawv, tsis yog tsuas yog cov kab mob uas muaj txiaj ntsig zoo uas pab zom zaub mov lossis tswj hwm lwm cov kab mob, tab sis kuj muaj cov kab mob uas muaj kab mob xws li Streptococcus mutans.Cov kab mob tsis zoo no tuaj yeem ua raws li cov hniav thiab sib sau ua "biofilm", noj cov suab thaj thiab tsim cov kua qaub uas ua rau cov hniav enamel, yog li paving txoj hauv kev rau "cov hniav lwj".

Clinically, stannous fluoride, silver nitrate los yog silver diamine fluoride feem ntau yog siv los tiv thaiv cov hniav plaque thiab tiv thaiv cov hniav lwj ntxiv.Tseem muaj cov kev tshawb fawb uas sim siv nanoparticles ua los ntawm zinc oxide, tooj liab oxide, thiab lwm yam los kho cov hniav lwj.Tab sis qhov teeb meem yog tias muaj ntau tshaj 20 cov hniav nyob rau hauv tib neeg lub qhov ncauj kab noj hniav, thiab tag nrho cov ntawm lawv muaj kev pheej hmoo ntawm eroded los ntawm cov kab mob.Kev rov siv cov tshuaj no tuaj yeem tua cov hlwb uas muaj txiaj ntsig thiab tseem ua rau muaj teeb meem ntawm cov tshuaj tiv thaiv ntawm cov kab mob phem.

Yog li ntawd, cov kws tshawb fawb vam tias yuav nrhiav txoj hauv kev los tiv thaiv cov kab mob uas muaj txiaj ntsig zoo hauv lub qhov ncauj thiab tiv thaiv cov hniav lwj.Lawv tig lawv cov xim rau cerium oxide nanoparticles (molecular mis: CeO2).Cov particle yog ib qho tseem ceeb ntawm cov khoom siv tshuaj tua kab mob thiab muaj qhov zoo ntawm cov tshuaj toxicity tsawg rau cov hlwb ib txwm thiab cov tshuaj tua kab mob raws li kev hloov pauv valence.Hauv xyoo 2019, cov kws tshawb fawb los ntawm Nankai University tau tshawb fawb txog qhov ua tau los tiv thaiv kab mobnanoparticles ntawm cerium oxidehauv Science China Materials.

Raws li cov kws tshawb fawb tau tshaj tawm ntawm lub rooj sib tham, lawv tau tsim cov cerium oxide nanoparticles los ntawm kev ua kom cov cerium nitrate los yog ammonium sulfate hauv dej, thiab kawm txog cov nyhuv ntawm cov khoom ntawm "biofilm" tsim los ntawm Streptococcus mutans.Cov txiaj ntsig tau pom tias txawm hais tias cov cerium oxide nanoparticles tsis tuaj yeem tshem tawm "biofilm", lawv txo nws txoj kev loj hlob los ntawm 40%.Raws li cov xwm txheej zoo sib xws, cov kws kho mob paub txog cov kab noj hniav tiv thaiv kab noj hniav nyiaj nitrate tsis tuaj yeem ncua sijhawm "biofilm".Kev loj hlob ntawm "membrane".

Tus kws tshawb fawb tseem ceeb ntawm txoj haujlwm, Russell Pesavento ntawm University of Illinois ntawm Chicago, tau hais tias: "Qhov zoo ntawm txoj kev kho mob no yog tias nws zoo li tsis muaj teeb meem rau cov kab mob hauv qhov ncauj.Nanoparticles tsuas yog tiv thaiv cov kab mob ntawm cov kab mob los ntawm adhering rau cov khoom thiab tsim ib tug biofilm.Thiab cov particle toxicity thiab metabolic cuam tshuam rau tib neeg lub qhov ncauj hlwb nyob rau hauv ib tug petri tais yog tsawg dua nyiaj nitrate nyob rau hauv cov qauv kev kho mob. 

Tam sim no, pab neeg no tab tom sim siv cov txheej txheem kom ruaj khov nanoparticles ntawm qhov nruab nrab lossis tsis muaj zog alkaline pH ze rau ntawm cov qaub ncaug.Nyob rau hauv lub neej yav tom ntej, cov kws tshawb fawb yuav sim cov txiaj ntsig ntawm qhov kev kho mob no rau tib neeg lub hlwb hauv cov plab hnyuv qis hauv cov kab mob hauv qhov ncauj ntau dua, txhawm rau muab cov neeg mob nrog kev nkag siab zoo ntawm kev nyab xeeb.