Ngati kutayika tsitsi ndi vuto kwa akuluakulu, ndiye kuti kuwola kwa mano (dzina la sayansi caries) ndi vuto lodziwika bwino la mutu kwa anthu azaka zonse.

Malinga ndi ziwerengero, kuchuluka kwa matenda a dental caries pakati pa achinyamata m'dziko lathu ndi oposa 50%, kuchuluka kwa matenda a mano pakati pa anthu azaka zapakati kumapitilira 80%, ndipo mwa okalamba, chiwerengerochi ndi choposa 95%.Ngati si mankhwala mu nthawi, izi wamba mano zolimba minofu bakiteriya matenda adzachititsa pulpitis ndi apical periodontitis, ndipo chifukwa kutupa kwa alveolar fupa ndi nsagwada fupa, amene kwambiri zimakhudza thanzi ndi moyo wa wodwalayo.Tsopano, matendawa mwina adakumana ndi "mdani".

Pa American Chemical Society (ACS) Virtual Conference and Exhibition in the Fall 2020, ofufuza ochokera ku yunivesite ya Illinois ku Chicago adanenanso za mtundu watsopano wa cerium nanoparticle formulation yomwe ingalepheretse kupangika kwa plaque ya mano ndi kuwola kwa mano mkati mwa tsiku limodzi.Pakalipano, ochita kafukufuku apempha chilolezo, ndipo kukonzekera kungagwiritsidwe ntchito kwambiri muzipatala zamano m'tsogolomu.

Mkamwa mwa munthu muli mitundu yoposa 700 ya mabakiteriya.Pakati pawo, palibe mabakiteriya opindulitsa okha omwe amathandiza kugaya chakudya kapena kulamulira tizilombo tina, komanso mabakiteriya ovulaza kuphatikizapo Streptococcus mutans.Mabakiteriya owopsa oterewa amatha kumamatira m'mano ndikusonkhanitsa kuti apange "biofilm", kudya shuga ndikupanga zinthu za acidic zomwe zimawononga enamel ya dzino, motero zimatsegula njira ya "kuwola kwa mano".

Kachipatala, stannous fluoride, silver nitrate kapena silver diamine fluoride nthawi zambiri amagwiritsidwa ntchito kuletsa zolembera za mano ndikuletsa kuwola kwina.Palinso maphunziro omwe akuyesera kugwiritsa ntchito nanoparticles opangidwa ndi zinc oxide, copper oxide, etc.Koma vuto ndi loti m’kamwa mwa munthu muli mano oposa 20, ndipo onse ali pachiopsezo chokokoloka ndi mabakiteriya.Kugwiritsa ntchito mankhwalawa mobwerezabwereza kumatha kupha maselo opindulitsa komanso kuyambitsa vuto la kukana mankhwala kwa mabakiteriya owopsa.

Choncho, ofufuza akuyembekeza kupeza njira yotetezera mabakiteriya opindulitsa omwe ali m'kamwa komanso kuti asawole.Anatembenukira ku cerium oxide nanoparticles (chilinganizo cha maselo: CeO2).Tinthu ndi chimodzi mwa zinthu zofunika antibacterial zipangizo ndipo ali ndi ubwino otsika kawopsedwe maselo wabwinobwino ndi antibacterial limagwirira zochokera kutembenuka reversible valence.Mu 2019, ofufuza aku Nankai University adafufuza mwadongosolo njira yothanirana ndi mabakiteriyacerium oxide nanoparticlesmu Science China Materials.

Malinga ndi lipoti la ochita kafukufuku pamsonkhanowo, adatulutsa cerium oxide nanoparticles mwa kusungunula cerium nitrate kapena ammonium sulfate m'madzi, ndipo adaphunzira zotsatira za particles pa "biofilm" yopangidwa ndi Streptococcus mutans.Zotsatira zinasonyeza kuti ngakhale kuti cerium oxide nanoparticles sakanatha kuchotsa "biofilm" yomwe ilipo, idachepetsa kukula kwake ndi 40%.Pazifukwa zofanana, anti-cavity agent silver nitrate sakanachedwetsa "biofilm".Kukula kwa "membrane".

Wofufuza wamkulu wa ntchitoyi, a Russell Pesavento wa pa yunivesite ya Illinois ku Chicago, anati: “Ubwino wa njira yochizirayi ndi yakuti ikuwoneka kuti siipa kwambiri mabakiteriya amkamwa.Nanoparticles amangoletsa tizilombo toyambitsa matenda kuti tisamamatire ku chinthucho ndikupanga biofilm.Ndipo kawopsedwe ka tinthu tating'onoting'ono komanso kagayidwe kachakudya m'maselo amkamwa amunthu m'mbale ya petri ndizocheperako kuposa siliva nitrate pochiza wamba. ” 

Pakadali pano, gululi likuyesera kugwiritsa ntchito zokutira kuti likhazikitse ma nanoparticles osalowerera ndale kapena ofooka amchere pH pafupi ndi malovu.M'tsogolomu, ochita kafukufuku adzayesa zotsatira za mankhwalawa pa maselo a anthu omwe ali m'mimba ya m'mimba mum'kamwa wambiri wa tizilombo tating'onoting'ono, kuti apereke odwala kukhala otetezeka.