M'zaka zaposachedwa, kulowererapo ndi kukhudzidwa kwa Nanotechchnology pa mankhwala, kuyenda ndi mankhwalawa kwawonekera. Nanotechnology ili ndi mwayi wosagwiritsidwa ntchito mu mankhwala osokoneza bongo komanso a mucal

Mankhwala osokoneza bongo pamlingo amagawidwa mthupi lonse pambuyo pa mtsempha wamkati, pakamwa kapena kamwaliyo, komanso kuchuluka kwa mankhwala osokoneza bongo osachita zochizira, kumabweretsanso mavuto. Chifukwa chake, kukula kwa mitundu yatsopano ya mankhwala kwakhala chitsogozo cha chitukuko chamakono, ndipo kafukufuku wa padongosolo loperekera mankhwala (mabadi) akhala malo otentha kwambiri mu kafukufuku wa pharmacy

Poyerekeza ndi mankhwala osokoneza bongo, onyamula mankhwala a Nano amatha kuzindikira mankhwala osokoneza bongo. Kutumiza mankhwala osokoneza bongo kumatanthauza kuti onyamula mankhwala omwe amathandizira onyamula, masingands kapena ma antibodies kuti asinthane ndi ma mankhwala osokoneza bongo kuti akwaniritse mafuta ozungulira, ma cell am'mudzi. Mothandizidwa ndi makina otsogolera, onyamula mankhwala osokoneza bongo amapulumutsa mankhwalawa pa chandamale ndipo amalimbitsa ochiritsa. Itha kukwaniritsa mankhwala othandiza ochepera, zotsatira zoyipa pang'ono, kusintha mankhwala osokoneza bongo, kuchuluka kwa bioavailability, ndipo nthawi yayitali yosungirako zinthuzo.

Kukonzekera komwe kumayang'aniridwa makamaka kunyamula, komwe kumagwiritsa ntchito tinthu tating'onoting'ono tofana ndi tinthu tofana tating'onoting'ono, chomwe chingapangitse tinthu tofana ndi tinthu toyambitsa chiwindi, ndulu, khwawa, lymph ndi magawo ena chifukwa cha thupi. Tdds amatanthauza mtundu watsopano wa njira zoperekera mankhwala omwe amatha kukhala ndi ma mankhwala osokoneza bongo, ziwalo, maselo kapena ma cell a intra kudzera m'magazi am'deralo kapena pathupi.

Kukonzekera mankhwala kwa nano kumayang'aniridwa. Amatha kuyang'ana kwambiri mankhwala omwe ali ndi gawo limodzi popanda vuto la ziwalo zosagwirizana. Amatha kukonza bwino mankhwala komanso kuchepetsa zovuta zina. Amawerengedwa kuti ndi mitundu yoyenera kwambiri yonyamula mankhwala osokoneza bongo. Pakadali pano, zinthu zina zomwe zimayang'aniridwa Nano zikuyenda pamsika, ndipo kukonzekera kwakukulu kwa nano kuli mu kafukufuku, omwe ali ndi chiyembekezo chothandiza pakumwa chotupa.

Mawonekedwe a Nano omwe adayesedwa:

⊙ Kuyang'anira: Mankhwalawa amakhazikika pamalo omwe mukufuna;

Chepetsani kuchuluka kwa mankhwala;

⊙ Sinthani mankhwala oyendetsera;

Kuchepetsa zoyipa za mankhwala. 

Kukonzekera kwa Nano-kukonzekera kumalumikizana kwakukulu ndi kukula kwa tinthu kokonzekera. Tinthu tating'onoting'ono tochepa 100nm zitha kudziunjikira mu fupa; tinthu tambiri a 100-200nm zitha kupatsidwa chotupa chotupa; Pomwe 0,2--3mum up mwachangu ndi macrophages mu ndulu; Tizilombo toyambitsa matenda 7 μm nthawi zambiri zimakodwa ndi pepu ya mapulopi a m'mapapo. Chifukwa chake, Kukonzekera kwa nano kumawonetsa zotsatira zosiyana chifukwa chakusiyana komwe kuli mankhwala omwe alipo, monga tinthu tating'onoting'ono ndi chindapusa. 

Zovala zomwe zimagwiritsidwa ntchito popanga zimaphatikizira ziweto za nano zomwe zimadziwika kuti zipatala ndi chithandizo zimaphatikizaponso:

(1) Zonyamula milid, monga Liposome nanoparticles;

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Mfundo zotsatirazi zimatsatiridwa nthawi zambiri pakusankhidwa kwa ngolo za nano:

(1) Kutsegula kwapamwamba kwa mankhwala osokoneza bongo ndi kuwongolera kwa mawonekedwe;

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(3) Ili ndi kukhazikika kwa colloidal.

(4) Kukonzekera kosavuta, kupanga kwakukulu kwakukulu, ndi mtengo wotsika 

Nano Gold Targetter

Golide (au) NanoparticlesKhalani ndi chidziwitso chabwino kwambiri ndi zotsekemera komanso zowoneka bwino, zomwe zitha kugwiritsidwa ntchito bwino mu rautherapy. Mwa kapangidwe kabwino, ma nano a Nano Traticles amathera kukhala minofu yotupa. A Au nanoparticles amatha kukulitsa mphamvu ya ma radiation m'derali, ndipo amathanso kusintha mphamvu zomwe mwakhala nazo kutentha kupha maselo a khansa m'derali. Nthawi yomweyo, mankhwala osokoneza bongo a Nano Active Cipangizo amatha kumasulidwa m'derali, kukulitsa njira yochizira. 

Nanoparticles amathanso kuyesedwa mwakuthupi. Nanorowders amakonzedwa ndi mankhwala osokoneza bongo ndi zinthu zam'madzi, ndipo pogwiritsa ntchito mphamvu zamatsenga mu vitro kuwongolera kuyenda kwa mankhwalawa m'thupi. Zinthu zomwe zimagwiritsidwa ntchito kwambiri, monga Fe₂O₃, akhala akuphunziridwa ndi kugwedeza mitoxantrone wokhala ndi dextran kenako ndikuwakoka₂O₃ kukonzekera nanoparticles. Kuyesa kwa pharmacokinetic kumachitika m'malo mwa mbewa. Zotsatira zake zinawonetsa kuti makonda a nanoparticles amatha kufika pamalo otupa, kuchuluka kwa mankhwala obowola mu malo otupa ndikokwera kuposa momwe zimakhalira ndi magazi.

Fe₃O₄watsimikiziridwa kuti ndi wopanda poizoni ndi bioom. Kutengera ndi mphamvu zapadera, zamagetsi, zamagetsi ndi magnetic, superparamine chitsulo cha ma oxide, chandamale ndipo monga chida chodzilekanitsa ndi kuyeretsedwa; Kukonza; kutumiza mankhwala; Kuganiza zamphamvu zanyukiliya; Chithandizo cha hyperthermia cha maselo a khansa, etc.

Carbon nanotubes (Cnts)Khalani ndi magawo apadera ndi miyala yamkati komanso yakunja, yomwe imatha kupanga luso lolowera la cell ndipo itha kugwiritsidwa ntchito ngati mankhwala a nanocarriers. Kuphatikiza apo, kapala ma nanotubes amakhalanso ndi ntchito yopeza zotupa ndikuchita mbali yoyenera kulembedwa. Mwachitsanzo, ma nanotubes amatenga gawo poteteza makonda a parathyroid panthawi ya chithokomiro. Itha kugwiritsidwanso ntchito ngati cholembera cha lymph node pakuchita opaleshoni, ndipo amatulutsa mankhwala osokoneza bongo a chemotherapy, omwe amapereka chiyembekezo chokhacho chopewera kupewa komanso kuchiza khansa ya coloretasis.

Kuwerenga, kugwiritsa ntchito nanotechnology mu minda ya mankhwala ndi mankhwala ali ndi chiyembekezo chabwino, ndipo zidzachititsa kuti magazini yatsopano yaukadaulo munyengo yazachuma ndi moyo wabwino.