Sanadihii la soo dhaafay, dhexgalka iyo saamaynta nanotechnology ee daawada, bioengineering iyo farmashiyaha ayaa muuqatay.Nanotechnology waxay leedahay faa'iido aan la bedeli karin ee farmashiyaha, gaar ahaan meelaha la beegsanayo iyo gaarsiinta daawada maxaliga ah, gaarsiinta daawada xuubka, daaweynta hidda-socodka iyo sii-deynta borotiinka iyo polypeptide la kantaroolay.

Daawooyinka qaababka qiyaasta caadiga ah ayaa loo qaybiyaa jirka oo dhan ka dib cirbadeynta xididada, afka ama gudaha, iyo qadarka daawooyinka dhabta ah ee gaarey aagga bartilmaameedka daaweynta waa qayb yar oo ka mid ah qiyaasta, iyo qaybinta inta badan daawooyinka meelaha aan bartilmaameedka ahayn. kaliya ma laha saameyn daweyn, waxay sidoo kale keeni doontaa waxyeelo sun ah.Sidaa darteed, horumarinta foomamka qiyaasta daawada cusub waxay noqotay jihada horumarinta farmashiyaha casriga ah, iyo cilmi-baarista habka bixinta daroogada ee bartilmaameedka ah (TDDS) waxay noqotay meel kulul ee cilmi-baarista farmashiyaha.

Marka la barbar dhigo daawooyinka fudud, sidayaasha daroogada nano waxay ogaan karaan daawaynta daroogada ee la beegsaday.Bixinta dawada la beegsaday waxaa loola jeedaa hab bixinta daawada kaas oo ka caawiya sideyaasha, ligands ama unugyada difaaca jirka si ay u xushaan daawooyinka si loo beegsado unugyada, xubnaha la beegsanayo, unugyada bartilmaameedka ama qaabdhismeedka unugyada gudaha iyada oo loo marayo maamulka degaanka ama wareegga dhiigga ee habaysan.Marka la eego ficilka hab hagitaan gaar ah, sidaha daroogada nano wuxuu gaarsiiyaa daawada bartilmaameed gaar ah wuxuuna sameeyaa saameyn daweyn.Waxay ku gaari kartaa daawo waxtar leh oo leh qiyaas yar, waxyeelo hoose, saameynta daawada joogtada ah, bioavailability sare, iyo sii-haynta muddada-dheer ee saameynta fiirsashada ee bartilmaameedyada.

Diyaargarowga inta badan waa diyaargarow sidayaal, kuwaas oo inta badan isticmaala walxaha ultrafine, kuwaas oo si door ah u soo ururin kara qaybahan kala firidhsan ee beerka, beeryarada, limfa iyo qaybaha kale sababtoo ah saameynta jireed iyo jireed ee jirka.TDDS waxa ay tilmaamaysaa nooc cusub oo ah habka gudbinta daawada kaas oo xooga saari kara oo ka dhigi kara dawooyinka unugyada buka, xubnaha, unugyada ama unugyada gudaha iyada oo loo marayo wareegga dhiigga ee maxaliga ah ama nidaamka.

Diyaargarowga daawada Nano ayaa la bartilmaameedsaday.Waxay ku ururin karaan daroogooyinka aagga bartilmaameedka leh oo saameyn yar ku leh xubnaha aan bartilmaameedka ahayn.Waxay wanaajin karaan waxtarka daroogada waxayna yareyn karaan waxyeelada nidaamka.Waxaa loo tixgeliyaa inay yihiin qaababka qiyaasta ugu habboon ee qaadista daawooyinka kansarka.Waqtigan xaadirka ah, qaar ka mid ah badeecooyinka diyaarinta nano-diyaarinta ee la beegsaday ayaa suuqa ku jira, tiro badan oo nano-diyaar garow ah ayaa ku jira marxaladda cilmi-baarista, kuwaas oo leh rajooyin ballaadhan oo codsi ah oo ku saabsan daaweynta burooyinka.

Sifooyinka diyaargarowga nano-ku wajahan:

⊙ Beegsiga: daawadu waxay ku urursan tahay aagga la beegsanayo;

⊙ Yaree qiyaasta daawada;

⊙ Hagaajinta saamaynta daawaynta;

⊙ Iska yaree waxyeelada daroogooyinka. 

Saamaynta la beegsanayo ee diyaar-garowga nano-ku-talagalka ah ayaa xidhiidh weyn la leh cabbirka qaybta diyaarinta.Qaybaha cabbirkoodu ka yar yahay 100nm waxay ku ururi karaan dhuuxa lafta;Qaybaha 100-200nm ayaa lagu hodmin karaa goobaha burooyinka adag;halka 0.2-3um kor loo qaado makrophages ee beeryarada;Qaybaha> 7 μm waxaa badanaa ku xayiran sariirta sambabada sambabada waxayna galaan unugyada sambabada ama alveoli.Sidaa darteed, diyaargarowga kala duwan ee nano waxay muujinayaan saameyno kala duwan oo bartilmaameed ah sababtoo ah kala duwanaanshaha xaaladda jiritaanka daroogada, sida xajmiga walxaha iyo kharashka dusha sare. 

Qaadayaasha sida caadiga ah loo isticmaalo dhismaha nano-platforms isku dhafan oo loogu talagalay ogaanshaha iyo daawaynta la beegsaday inta badan waxaa ka mid ah:

(1) Xambaarayaasha dufanka leh, sida nanoparticles liposome;

(2) Sidayaal polymer-ka ah, sida polymer dendrimers, micelles, vesicles polymer, block copolymers, protein nano particles;

(3) Sidayaal aan dabiici ahayn, sida qaybo silikoon ku salaysan nano, nanoparticles kaarboon ku salaysan, nanoparticles magnetic, nanoparticles bir ah, iyo nanomaterials kor-rogid, iwm.

Mabaadi'da soo socota ayaa guud ahaan la raacaa xulashada nano sideyaal:

(1) Heerka raraynta maandooriyaha oo sarreeya iyo sifooyin la xakameeyey;

(2) Sunta bayoolojiga oo hoosaysa iyo jawaab difaac oo aan sal lahayn;

(3) Waxay leedahay xasillooni kolloid oo wanaagsan iyo xasilloonida jireed;

(4) Diyaarin fudud, wax-soo-saar baaxad weyn oo fudud, iyo qiimo jaban 

Nano Gold Therapy

Dahab (Au) nanoparticleswaxay leeyihiin dareen shucaac ah oo aad u fiican iyo sifooyinka indhaha, kuwaas oo si fiican loogu dabaqi karo daaweynta shucaaca ee la beegsaday.Iyada oo loo marayo naqshad fiican, qaybaha dahabka nano waxay si togan ugu ururin karaan unugyada burooyinka.Au nanoparticles waxay kor u qaadi karaan waxtarka shucaaca aaggan, waxayna sidoo kale u beddeli karaan tamarta iftiinka shilka ee la nuugo kulayl si ay u dilaan unugyada kansarka ee aagga.Isla mar ahaantaana, daroogooyinka dusha sare ee qaybaha nano Au ayaa sidoo kale lagu sii deyn karaa aagga, taas oo sii kordhinaysa saameynta daaweynta. 

Nanoparticles sidoo kale waa la bartilmaameedsan karaa jir ahaan.Nanopowders waxaa lagu diyaariyaa iyada oo la duubo daroogooyinka iyo walxaha ferromagnetic, iyo isticmaalka saamaynta magnetic field in vitro si ay u hagto dhaqdhaqaaqa jihada iyo meelaynta daroogada ee jirka.Walxaha magnetic sida caadiga ah loo isticmaalo, sida Fe₂O₃, ayaa lagu bartay isku-xidhka mitoxantrone oo leh dextran ka dibna ku duub Fe₂O₃ si loo diyaariyo nanoparticles.Tijaabooyin farmacokinetic ah ayaa lagu sameeyay jiirarka.Natiijooyinku waxay muujiyeen in nanoparticles si magnetic ahaan loo beegsaday ay si dhakhso ah u iman karaan oo ay joogi karaan goobta burada, fiirsashada daawooyinka magnetically bartilmaameedka ah ee goobta burada ayaa ka sarreeya unugyada caadiga ah iyo dhiigga.

Fe₃O₄waxa la caddeeyey in aanu sun ahayn oo la socon kara.Iyada oo ku saleysan sifooyinka jireed ee gaarka ah, kiimikooyinka, kulaylka iyo magnetic, superparamagnetic birta oxide nanoparticles waxay leeyihiin awood weyn oo lagu isticmaalo noocyo kala duwan oo biomedical ah, sida calaamadaynta unugyada, bartilmaameedka iyo sida aaladda cilmi-baarista unugyada deegaanka, daaweynta unugyada sida kala-soocidda unugyada iyo nadiifinta;hagaajinta unugyada;gaarsiinta daroogada;sawirka magnetic resonance nukliyeerka;hyperthermia daaweynta unugyada kansarka, iwm.

Kaarboon nanotubes (CNTs)waxay leeyihiin qaab-dhismeed godan oo gaar ah iyo dhexroor gudaha iyo dibadda ah, kaas oo samayn kara awoodaha gelitaanka unugga oo aad u wanaagsan oo loo isticmaali karo sida nanocarriers daroogada.Intaa waxaa dheer, kaarboon nanotubes sidoo kale waxay leeyihiin shaqada lagu ogaanayo burooyinka waxayna door wanaagsan ka ciyaaraan calaamadeynta.Tusaale ahaan, kaarboon nanotubes ayaa door ka ciyaara ilaalinta qanjidhada parathyroid inta lagu jiro qalliinka tayroodh.Waxa kale oo loo isticmaali karaa calaamad ahaan qanjidhada qanjidhada xilliga qalliinka, waxayna leedahay shaqada dawooyinka kemotherabi ee tartiib-tartiib u sii daaya, taas oo bixisa rajooyin ballaadhan oo ka hortagga iyo daaweynta kansarka mindhicirka.

Si loo soo koobo, codsiga nanotechnology ee goobaha caafimaadka iyo farmashiyaha waxay leedahay rajo wanaagsan, waxaana hubaal ah inay keeni doonto kacaan cusub oo teknoloji ah oo ku saabsan daawada iyo farmashiyaha, si ay u sameeyaan wax cusub oo ku saabsan horumarinta caafimaadka aadanaha iyo tayada nolosha.