Ukuba ukulahleka kweenwele kuyingxaki kubantu abadala, ke ukubola kwamazinyo (igama lesayensi caries) yingxaki eqhelekileyo yentloko kubantu bayo yonke iminyaka.

Ngokweenkcukacha-manani, ukubakho kwe-caries yamazinyo phakathi kwabafikisayo kwilizwe lam kungaphezu kwama-50%, izehlo ze-caries zamazinyo phakathi kwabantu abaphakathi kweminyaka yobudala zingaphezu kwama-80%, kwaye phakathi kwabantu abadala, umlinganiselo ungaphezu kwama-95%.Ukuba anyangwa kwangethuba, esi sifo eqhelekileyo yamazinyo nzima lwebhaktheriya izicubu kuya kubangela pulpitis kunye periodontitis apical, kwaye nokuba ukudumba ithambo alveolar kunye nomhlathi ithambo, nto leyo eya kuchaphazela ngokunzulu impilo kunye nobomi besigulane.Ngoku, esi sifo sinokuthi sidibane “notshaba.”

KwiNkomfa ye-American Chemical Society (ACS) yeNgqungquthela ye-Virtual kunye neMboniso kwi-Fall 2020, abaphandi abavela kwiYunivesithi yase-Illinois e-Chicago babike uhlobo olutsha lwe-cerium nanoparticle formulation olunokuthintela ukubunjwa kwamazinyo kunye nokubola kwamazinyo ngosuku olunye.Okwangoku, abaphandi baye bafaka isicelo kwi-patent, kwaye ukulungiswa kunokusetyenziswa ngokubanzi kwiikliniki zamazinyo kwixesha elizayo.

Kukho ngaphezu kwe-700 iintlobo zeebhaktheriya emlonyeni womntu.Phakathi kwazo, akukho bhaktheriya enenzuzo kuphela enceda ukugaya ukutya okanye ukulawula ezinye ii-microorganisms, kodwa kunye neebhaktheriya ezinobungozi ezibandakanya i-Streptococcus mutans.Iibhaktheriya ezinobungozi ezinjalo zinokubambelela kumazinyo kwaye ziqokelele ukuze zenze "i-biofilm", zidle iswekile kwaye zivelise i-acidic byproducts eyonakalisa i-enamel yezinyo, ngaloo ndlela ivula indlela "yokubola kwamazinyo".

Ngokonyango, i-stannous fluoride, isilivere ye-nitrate okanye i-silver diamine fluoride ihlala isetyenziselwa ukuthintela iplaque yamazinyo kunye nokuthintela ukubola kwamazinyo ngakumbi.Kukho nezifundo ezizama ukusebenzisa i-nanoparticles ezenziwe nge-zinc oxide, i-copper oxide, njl njl. ukunyanga ukubola kwamazinyo.Kodwa ingxaki kukuba kukho amazinyo angaphezu kwama-20 kumngxuma womlomo womntu, kwaye onke asemngciphekweni wokutshatyalaliswa yintsholongwane.Ukusetyenziswa ngokuphindaphindiweyo kwala mayeza kunokubulala iiseli eziluncedo kwaye kubangele nengxaki yokunganyangeki kweziyobisi kwiintsholongwane eziyingozi.

Ngoko ke, abaphandi banethemba lokufumana indlela yokukhusela iintsholongwane eziluncedo kumngxuma womlomo nokuthintela ukubola kwamazinyo.Bajika ingqalelo yabo kwi-cerium oxide nanoparticles (i-molecular formula: CeO2).I-particle yenye yezinto ezibalulekileyo zokulwa ne-antibacterial kwaye ineenzuzo ze-toxicity ephantsi kwiiseli eziqhelekileyo kunye ne-antibacterial mechanism esekelwe ekuguquleni ukuguqulwa kwe-valence.Ngo-2019, abaphandi abavela kwiYunivesithi yaseNankai baphonononge ngokucokisekileyo indlela enokwenzeka yokulwa ne-antibacteriali-cerium oxide nanoparticleskwiSayensi China Materials.

Ngokwengxelo yabaphandi kwinkomfa, bavelisa i-cerium oxide nanoparticles ngokuchithwa kwe-cerium nitrate okanye i-ammonium sulfate emanzini, kwaye bafunda umphumo weengqungquthela kwi "biofilm" eyenziwe yiStreptococcus mutans.Iziphumo zibonise ukuba nangona i-cerium oxide nanoparticles ayikwazanga ukususa "i-biofilm" ekhoyo, yanciphisa ukukhula kwayo nge-40%.Ngaphantsi kweemeko ezifanayo, i-agent ye-anti-cavity yesilivere ye-nitrate eyaziwa ngokuba yikliniki ayikwazanga ukulibazisa "i-biofilm".Ukuphuhliswa kwe "membrane".

Umphandi ophambili wale projekthi, uRussell Pesavento weYunivesithi yase-Illinois eChicago, wathi: “Inzuzo yale ndlela yonyango kukuba ibonakala ingenabungozi kangako kwiintsholongwane ezisemlonyeni.I-Nanoparticles iya kuthintela kuphela i-microorganisms ukuba ibambelele kwizinto kunye nokwenza i-biofilm.Kwaye ubutyhefu besuntswana kunye neziphumo zemetabolism kwiiseli zomlomo womntu kwisitya se-petri zingaphantsi kwe-nitrate yesilivere kunyango oluqhelekileyo. 

Okwangoku, iqela lizama ukusebenzisa iingubo zokuzinzisa i-nanoparticles kwi-pH engathathi hlangothi okanye engenamandla e-alkaline kufuphi ne-saliva.Kwixesha elizayo, abaphandi baya kuvavanya umphumo wolu nyango kwiiseli zomntu kwi-digestive tract kwi-flora ye-microbial yomlomo epheleleyo, ukwenzela ukubonelela izigulane ngengqiqo engcono yokhuseleko.