Kwiminyaka yakutshanje, ukungena kunye nefuthe le-Nanotechnology kwiyeza, i-bioengine kunye nekhemisi ibonakale. I-nanotechnology inengenelo ebonakalayo kwikhemesti, ngakumbi kumasimi ejolise kwiziyobisi, ukuhanjiswa kweziyobisi, ukuhanjiswa kweziyobisi, ukukhutshwa kwe-gene, ukukhutshwa kweproteyini kunye nepolypeptide

Iziyobisi kwiifom ze-dosage eziqhelekileyo zisasazwa kuwo wonke umzimba emva kwenaliti, ngomlomo, kunye nenani lamachiza afikelela kwi-DOSE i-DOSE ye-DOSE, kwaye ukwabiwa kwezixhobo ezingabizi zizinto ezingenazonyango, ziya kuzisa iziphumo ezibi kakhulu. Ke ngoko, ukuphuculwa kweefom zethamo ezintsha zeziyobisi kube lulawulo lophuhliso lwekhemesti yale mihla, kunye nophando malunga nenkqubo ekujoliswe kuyo iziyobisi (i-TDDS) iye yaba yindawo eshushu kuphando lwekhemesti

Xa kuthelekiswa neziyobisi ezilula, abathwali be-Nano banokuqonda unyango olujolise lweziyobisi. Ukuhanjiswa kweziyobisi kubhekisa kwinkqubo yokuhambisa iziyobisi enceda abathwali, i-ligands okanye ii-antibodies ukuba zithathele ingqalelo iziyobisi ukuba zijolise kwizicubu, iiseli ekujoliswe kuzo ngolawulo lwasekhaya okanye ukujikeleza kwegazi kwegazi. Phantsi kwesenzo sendlela ethile yesikhokelo, umthwali weziyobisi uNano unikezela ichiza kwithagethi ethile kwaye enza ifuthe elinengxaki. Inokufezekisa ichiza elisebenzayo kunye ne-dosage encinci, iziphumo ebezingalindelekanga, impembelelo ezinzileyo, i-biousaif ephakamileyo, kunye nokugcinwa kwexesha elide kwimpembelelo yoxinzelelo kwiithagethi.

Amalungiselelo ajongiweyo ikakhulu amalungiselelo, esebenzisa kakhulu amasuntswana e-Ultrafine, enokukhetha ukuhlanganisa abasasazi kwiSibindi, i-Spreen, i-lymph namanye amalungu ngenxa yemizimba yezasemzimbeni nasemzimbeni. Ii-TDDs zibhekisa kuhlobo olutsha lwenkqubo yokuhanjiswa kweziyobisi ezinokugxila kwaye zenze amachiza kwizicubu ezinesifo, amalungu, iiseli okanye ukujikeleza kwegazi kwegazi.

Amalungiselelo amayeza eNano ajolise kuyo. Banokugxila iziyobisi kwindawo ekujoliswe kuyo enefuthe elincinci kumalungu angabizi. Banokuphucula ukusebenza kweziyobisi kunye nokunciphisa iziphumo ebezingalindelekanga. Zithathwa njengezona ntlobo zenzamo ezifanelekileyo zokuthwala iziyobisi. Okwangoku, ezinye zeemveliso ze-NAno ezijolise kwi-Nano zisemarikeni, kwaye inani elikhulu lamalungiselelo e-NAno olujolisiweyo likwinqanaba lophando, elinethemba elibanzi lokufumana unyango lwethumba.

Iimpawu zamalungiselelo e-NAAno ekujoliswe kuwo:

⊙ Ukujolisa: Ichiza ligxilwe kwindawo ekujoliswe kuyo;

⊙ wisa idosi yamayeza;

⊙ Ukuphucula isiphumo soqobo;

⊙ Ukucutha iziphumo ebezingalindelekanga zeziyobisi. 

Iziphumo ekujoliswe kuzo ze-nano ezijolise kwi-nano zinelungelo elikhulu ngobukhulu becala lokulungiselela. Amasuntswana anobungakanani ngaphantsi kwe-100nm anokuqokelela kumongo wethambo; Amasuntswana e-100-200mm angaqeshwa kwiindawo eziqinileyo zetora; Ngelixa i-0,2-3um iphakanyiswe nguMakrages egxeni; Amasuntswana> I-7 μm zihlala zibanjelwe yibhedi ye-palmonary capillary kwaye zingena kwizicubu ze-ling okanye i-alveli. Ke ngoko, amalungiselelo ahlukeneyo nano awahlukeneyo abonisa iziphumo ezijolise kuzo ngenxa yomahluko kwimeko yobukho beziyobisi, ezinje ngobukhulu becala kunye nentlawulo engaphezulu. 

Abathwali abasetyenziswa ngokuqhelekileyo ukwakha amaqonga ahlanganisiweyo e-Nano ehlanganisiweyo yokuxilongwa kunye nokunyanga ikakhulu kubandakanya:

(1) Abathwali be-lipid, abanjengeLipolontlentle into;

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Le migaqo ilandelayo ilandelwa ngokubanzi ekukhetheni iiCarriers ze-nano:

(1) Ixabiso lokufaka iziyobisi ephezulu kunye neempawu zokukhutshwa kweziyobisi;

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(3) Inozinzo oluhle nozinzo lomzimba;

(4) Ukulungiswa okulula, ukuveliswa okulula kunye nokuhlawulwa kwexabiso eliphantsi 

I-NAO Gold I-Nareged Unyango

IGold (AU) I-NanoparticlesUnemvakalelo ye-radiation ye-radiation efanelekileyo kunye neepropathi ezibonakalayo, ezinokufakwa kakuhle kunyango lwe-radiotherapy. Ngoyilo oluchanekileyo, amasuntswana egolide egolide anokuqokelela ngokuchanekileyo kwizicubu ze-tumar. I-AU Nanopalicals inokuphucula ukusebenza kwe-radiation kule ndawo, kwaye inokuguqula amandla angenamandla okukhanya kubushushu ukubulala iiseli zomhlaza kule ndawo. Kwangelo xesha, amachiza asemagqabini eNano Au anokukhululwa kuloo ndawo, ekwandisa isiphumo sonyango. 

I-Nanopalicals ikwanokujoliswa ngokwasemzimbeni. Ababhali be-nanopowdy balungiselelwe ukusonga iziyobisi kunye nezinto ze-ferroomagnetic, kwaye besebenzisa isiphumo se-magnetic vitro ukukhokela intshukumo yeziyobisi kunye nokufakwa kwamachiza emzimbeni. Izinto eziqhelekileyo ezisetyenziswayo zemagnethi, ezinjenge-fe₂O₃, ifundwe ngokudibanisa i-mitoxantle enee-debextrane kwaye emva koko ingenelele nge-fe₂O₃ ukulungiselela i-nanoparcrles. Iimvavanyo ze-pharmaconkinictictic zenziwa kwiimpuku. Iziphumo zibonise ukuba i-Nanopalicaly ejolise ka-Nanttieness inokufika ngokukhawuleza kwaye ihlale kwindawo yethumba, ukugxila kweziyobisi ekujoliswe kuwo ngaphandle kwendawo ye-tummar kuphakamile kunezixhobo eziqhelekileyo kunye negazi.

Fe₃O₄iqinisekisiwe ukuba inganetyhefu kwaye i-biompatid. Isekwe kwipropathi eyodwa yomzimba, yekhemikhali, i-themic kunye ne-themic, i-supermaramiclic yentsimbi ye-ANOXIME i-Nanaprics ineempawu eziphezulu ze-biomeding, njengezixhobo zeseli kwiseli, inyanga yeseli efana nokwahlukana neseli kunye nokucocwa kweseli; Ukulungiswa kwezicubu; Ukuhanjiswa kweziyobisi; I-Nulearnear Dougneting icinga; Unyango lwe-hyperthermia yeeseli zomhlaza, njl.

I-carbon natoutubs (i-cvents)Yiba nesakhiwo esahlukileyo kunye ne-diameter yangaphakathi nengaphandle, enokwenza ubuchule obugqwesileyo beseli kwaye bunokusetyenziswa njengeziyolo ze-nanocarriers. Ukongeza, i-carbon nanobis natwes ikwanomsebenzi wokuchonga amathumba kwaye adlale indima elungileyo ekumatshisweni. Umzekelo, i-carbon nanobi idlala indima ekukhuseleni amadlala eParathyroid ngexesha lotyando we-hyroid. Ingasetyenziselwa njengokumakisha ii-lymph node ngexesha lotyando, kwaye inomsebenzi weyeza lokukhupha kancinci, elinika amathuba okunyanga okuthintela unyango kunye nonyango lwe-coloctal metastasis.

Ukuzama ukuphakama, ukusetyenziswa kwe-nanotechnology kwicandelo leyeza kunye nekhemisi elinethemba eliqaqambileyo, kwaye ngokuqinisekileyo kuya kubangela utshintsho lweteknoloji entsha kwicandelo lezamayeza kunye nekhemisi ekuphuculeni impilo kunye nomgangatho wobomi.