Uma ukulahlekelwa izinwele kuyinkinga kubantu abadala, khona-ke ukubola kwamazinyo (igama lesayensi i-caries) kuyinkinga evamile yekhanda kubantu bayo yonke iminyaka.

Ngokwezibalo, izigameko zokucasuka kwamazinyo entsheni ezweni lami zingaphezu kuka-50%, izigameko zokucasuka kwamazinyo kubantu abaneminyaka ephakathi zingaphezu kwama-80%, kanti kubantu asebekhulile, inani lingaphezu kwama-95%.Uma kungelashwa ngesikhathi, lesi sifo esivamile se-bacterial yamazinyo esiqinile sizodala i-pulpitis kanye ne-apical periodontitis, futhi sibangele ngisho nokuvuvukala kwethambo le-alveolar kanye nethambo lomhlathi, okuzothinta kakhulu impilo nokuphila kwesiguli.Manje, lesi sifo kungenzeka sihlangane “nesitha.”

Ku-American Chemical Society (ACS) Virtual Conference and Exhibition in the Fall 2020, abacwaningi abavela eNyuvesi yase-Illinois e-Chicago babike uhlobo olusha lokwakhiwa kwe-cerium nanoparticle olungavimbela ukwakheka kwe-plaque yamazinyo nokubola kwamazinyo phakathi nosuku olulodwa.Njengamanje, abacwaningi bafake isicelo selungelo lobunikazi, futhi ukulungiswa kungase kusetshenziswe kabanzi emitholampilo yamazinyo esikhathini esizayo.

Kunezinhlobo ezingaphezu kuka-700 zamagciwane emlonyeni womuntu.Phakathi kwabo, akukhona nje kuphela amabhaktheriya anenzuzo asiza ukugaya ukudla noma ukulawula amanye ama-microorganisms, kodwa futhi namabhaktheriya ayingozi ahlanganisa i-Streptococcus mutans.Amagciwane anjalo ayingozi anganamathela emazinyweni futhi ahlangane ukuze enze “i-biofilm”, adle ushukela futhi akhiqize imikhiqizo ene-asidi egqwala koqweqwe lwawo lwamazinyo, ngaleyo ndlela evula indlela “yokubola kwamazinyo”.

Ngokomtholampilo, i-stannous fluoride, i-silver nitrate noma i-silver diamine fluoride ivame ukusetshenziselwa ukuvimbela uqweqwe lwamazinyo nokuvimbela ukubola kwamazinyo.Kukhona nezifundo ezizama ukusebenzisa ama-nanoparticles enziwe nge-zinc oxide, i-copper oxide, njll. ukwelapha ukubola kwamazinyo.Kodwa inkinga iwukuthi kunamazinyo angaphezu kuka-20 emlonyeni womuntu, futhi wonke asengozini yokuguguleka amagciwane.Ukusetshenziswa ngokuphindaphindiwe kwale mithi kungabulala amangqamuzana awusizo futhi kubangele ngisho nenkinga yokungazweli emishanguzweni yamagciwane ayingozi.

Ngakho-ke, abacwaningi banethemba lokuthola indlela yokuvikela amagciwane azuzisayo emlonyeni nokuvimbela ukubola kwamazinyo.Baphendukela ku-cerium oxide nanoparticles (ifomula yamangqamuzana: CeO2).I-particle ingenye yezinto ezibalulekile ze-antibacterial futhi inezinzuzo zobuthi obuphansi kumaseli avamile kanye nendlela ye-antibacterial esekelwe ekuguquleni i-valence ehlehliswayo.Ngo-2019, abacwaningi abavela eNyuvesi yaseNankai bahlola ngokuhlelekile indlela engase ibe khona ye-antibacteriali-cerium oxide nanoparticleskwezeSayensi China Materials.

Ngokombiko wabacwaningi engqungqutheleni, bakhiqiza i-cerium oxide nanoparticles ngokuhlakaza i-cerium nitrate noma i-ammonium sulfate emanzini, futhi bafunda umphumela wezinhlayiya ku-"biofilm" eyenziwe yi-Streptococcus mutans.Imiphumela yabonisa ukuthi nakuba i-cerium oxide nanoparticles ayikwazanga ukususa "i-biofilm" ekhona, yanciphisa ukukhula kwayo ngo-40%.Ngaphansi kwezimo ezifanayo, i-agent anti-cavity silver nitrate eyaziwa ngokomtholampilo ayikwazanga ukubambezela “i-biofilm”.Ukuthuthukiswa kwe "membrane".

Umcwaningi oyinhloko wale phrojekthi, uRussell Pesavento waseNyuvesi yase-Illinois e-Chicago, wathi: “Inzuzo yale ndlela yokwelapha ukuthi ibonakala ingenabungozi kangako kumagciwane omlomo.Ama-nanoparticles azovimbela kuphela ama-microorganisms ukuthi anamathele entweni futhi enze i-biofilm.Futhi ubuthi bezinhlayiyana kanye nemiphumela ye-metabolic kumaseli omlomo womuntu esitsheni se-petri ingaphansi kwe-nitrate esiliva ekwelapheni okujwayelekile.” 

Njengamanje, ithimba lizama ukusebenzisa okokunamathela ukuze lizinzise ama-nanoparticles ku-pH engathathi hlangothi noma ene-alkali ebuthakathaka eduze naleyo yamathe.Ngokuzayo, abacwaningi bazohlola umphumela walokhu kwelashwa kumangqamuzana omuntu asendaweni ephansi yokugaya ukudla esitshalweni se-microbial esiphelele somlomo, ukuze banikeze iziguli umuzwa ongcono wokulondeka.